What is granulation tissue?

Granulation tissue refers to the new connective tissue and microscopic blood vessels that are formed during the healing process of a wound. This tissue typically appears as a pink or red granular substance that fills the wound bed, indicating that the body is actively working to repair itself. The fresh tissue plays a crucial role by providing a temporary matrix that supports the migration of new cells, ultimately leading to the closure of the wound.

Granulation tissue is composed of a variety of cells, including fibroblasts, which synthesize collagen, and endothelial cells, which form new blood vessels. This process is essential for healing because it not only helps in closing the wound but also ensures adequate blood supply and oxygenation to the area, fostering further healing and regeneration. In contrast, a thick layer of scab is a protective barrier formed from dried blood and serum that can sometimes cover a wound but is not indicative of the healing process itself. Accumulation of dead skin cells or infected tissue would not contribute positively to wound healing and can, in fact, hinder recovery. Therefore, the definition of granulation tissue as new connective tissue that forms over a wound distinctly highlights its importance in the healing process.